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Hyaluronic Acid 0.8 - 1.5 million Da
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Definition: Hyaluronic acid abbreviated HA; conjugate base hyaluronate, also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans as it is non-sulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large: human synovial HA averages about 7 million Da per molecule, or about 20,000 disaccharide monomers, while other sources mention 3–4 million Da. As one of the chief components of the extracellular matrix, it contributes significantly to cell proliferation and migration, and is involved in the progression of many malignant tumors. The average 70 kg (150 lb) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (i.e., degraded and synthesized) per day. Hyaluronic acid is also a component of the group A streptococcal extracellular capsule, and is believed to play a role in virulence.
Application: It has function of moisturizing and joint lubricating. Different forms of hyaluronic acid are used for cosmetic purposes. Hyaluronic acid might also affect the way the body responds to injury and help to decrease swelling. Hyaluronic acid injections are US FDA-approved for several conditions, including cataracts, osteoarthritis, and as an injectable gel filler (Juvedérm) for facial wrinkles. People also commonly take hyaluronic acid by mouth and apply it to the skin for UTIs, acid reflux, dry eyes, wound healing, aging skin, and many other conditions
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